Katalin Kariko on Starting a Family; Partner Dynamics
  Katalin Kariko     Biography    
Recorded: 27 Sep 2023

Oh, no. My husband is just very similar to an attitude how I am. I can completely get into the science, and reading, and understanding, and he was in the garage, and he purchased cars that mostly were coming on trailer, and then he sold it, and we had 150 cars. He fixed them up, and he sold, and he made extra money from that, and he did painting, also, and there are many other things. At one point my daughter and I were driving cars that he changed the engine in our garage, and those cars were not from the '60s. Those were with all-electric, all of the computerized things, and he could do it.

He did here, and yes, he also made our furniture, so my cabinet, my table, the bed, and all of the tables, because his father was a carpenter, and he did also furniture carpentry, and then in Hungary, we learned our parents' profession, so I was a butcher, he could make furniture. [chuckles]

Dr. Katalin Kariko is a biochemist and adjunct professor of neurosurgery at the University of Pennsylvania. She won the 2023 Nobel Prize in Physiology or Medicine for her work in developing mRNA vaccines against COVID-19. She completed her schooling at the University of Szeged and carried out her post-doctoral work at the Institute of Biochemistry, Biological Research Centre of Hungary.

Dr. Kariko received her Bachelor of Sciences in Biology in 1978 and her PhD in Biochemistry in 1982 from the University of Szeged. She completed her post-doctoral work at the Institute of Biochemistry, Biological Research Centre of Hungary until 1985, when her lab at the Biological Research Centre lost funding. She then moved to the United States and carried out post-doctoral work at Temple University from 1981 to 1988 and at the Uniformed Services University of the Health Sciences from 1988 to 1989. She then joined the faculty of the University of Pennsylvania in the Perelman School of Medicine’s neurosurgery department in 1989.

At the University of Pennsylvania, she began to collaborate with immunologist Drew Weissman, where the two experimented with modifying mRNA. In the early 2000’s, Kariko and Weissman discovered that swapping uridine with pseudouridine in mRNA created a molecule with favorable attributes such as reduced adverse reactions. This breakthrough led the way for many other modified mRNA molecules to be potentially used in a multitude of future medical applications, including developing effective mRNA vaccines against the COVID-19 virus during the height of the pandemic in 2020. For their development of mRNA biotechnology, Dr. Kariko and Dr. Weissman were awarded the 2023 Nobel Prize in Physiology or Medicine.

Outside of the Nobel Prize, Dr. Kariko has received numerous awards for her contributions to science including the Lasker-DeBakey Clinical Medical Research Award in 2021, the Novo Nordisk Prize in 2022, being inducted into the National Inventors Hall of Fame in 2023, the Harvey Prize in Human Health in 2024, and elected to the National Academy of Sciences in 2025.

SCIENTISTS SPEAKING ABOUT BECOMING A SCIENTIST
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